18 Jan 2021. Smith grew up in Illinois in the 1930s and 40s, when molecular biology was emerging as a branch of science, much of it focused on the nature of genes. DANIEL NATHANS October 30, 1928–November 16, 1999 BY DANIEL DIMAIO D ANIEL NATHANS, A SCIENTIST whose pioneering use of restriction endonucleases revolutionized virology and genetics and whose personal qualities had a profound impact on those who knew him, passed away in November 1999 at the age of 71. But an epiphany was coming, and it involved discovery of the structure of DNA in 1953. Daniel Nathans and Werner Arber shared the 1978 Nobel Prize with Hamilton Smith for their investigations dealing with the restriction endonucleases and their relevance to molecular genetics. Ham is always so fair. PMID 368662. Photographic Print. degree in mathematics at the University of California, Berkeley in 1952 and the M.D. “I didn’t care what other people thought.”. “Then he put them where he thought they should be and listed me as first author. Johns Hopkins, 1956. Daniel Nathans (October 30, 1928 - November 16, 1999) was an American biologist.He won the Nobel Prize in Physiology or Medicine in 1978. Werner Arber is a Swiss microbiologist who, along with Daniel Nathans and Hamilton Smith of the US, received the 1978 Nobel Prize in physiology or medicine for the discovery of “restriction enzymes and their application to problems of molecular genetics”. Along with American researchers Hamilton Smith and Daniel Nathans, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction endonucleases. Tasked with a mission to manage Alfred Nobel's fortune and has ultimate responsibility for fulfilling the intentions of Nobel's will. Discovered by Daniel Nathans, Werner Arber, and Hamilton Smith in the 1970s, these "molecular scissors" cut DNA in a controlled manner. I. Purification and general properties. "[Werner Arber, Daniel Nathans and Hamilton Smith. They can be used cut genes into pieces, which enables scientists to do such things as determine the order of genes on chromosomes and to alter genes. Daniel Nathans and Hamilton Smith in the lab. Kroon, A M (February 1979). PMID 368662. “I’m slipping away pretty fast now,” said Smith, who is known for his calmness and candor. Mayo Clin. That’s how he made his early discoveries with restriction enzymes.”. Nathans and Smith, Daniel Nathans (1928–1999) and Hamilton Othanel Smith (1931– ) The content above is only an excerpt. Born in 1928, Dr. Daniel Nathans was the ninth and youngest child of Russian Jewish immigrant parents. in studying the nature of genes. It was a public-private venture. Smith adapted to the overwhelming experience of being named a laureate. Nathans recognized that such an enzyme would be useful for making uniform fragments of a small virus DNA that could then be mapped, i.e., the precise molecular structure determined. Daniel Nathans was born on October 30th, 1928. It goes with his gentle nature. Their work with restriction enzymes would apply to all disciplines of biological, biochemical, cell biological, and biomedical sciences. 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Early on, he didn’t find it that compelling and studied at UC Berkeley, where he earned a bachelor’s degree in mathematics in 1952. The collective work of Smith and fellow scientists Werner Arber and Daniel Nathans led to them being jointly awarded the 1978 Nobel Prize in physiology or medicine — an honor Smith found hard to deal with. 71 (4): 360. "[Werner Arber, Daniel Nathans and Hamilton Smith. Swiss microbial geneticist, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine with Hamilton Smith and Daniel Nathans for their discovery of restriction endonucleases. Nathans, Werner Arber and Hamilton O. Smith shared the Nobel Prize in Physiology or Medicine in 1978 for their work on the discovery of restriction enzymes and their application to the problems of molecular genetics. Daniel Nathans was an American microbiologist who received the Nobel Prize in Physiology or Medicine in 1978 along with Hamilton Othanel Smith of the United States and Werner Arber of Switzerland. of Michigan and Johns Hopkins, Smith worked with Daniel Nathans and Werner Arber studying the nature of genes..... Click the link for more information. "The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)". Swiss microbial geneticist, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine with Hamilton Smith and Daniel Nathans for their discovery of restriction endonucleases. Township resident Daniel A. Smith … 1978-ban a restrikciós endonukleázok felfedezéséért Daniel Nathans, Hamilton O. Smith és a svájci Werner Arber megkapta az orvostudományi Nobel-díjat. Jaden Christopher Syre Smith is a well-known actor and rapper from Malibu, California, and is the son of celebrities Jada Pinkett Smith and Will Smith. “It is difficult for me to hear of his retirement. While he was in Israel, Hamilton Smith, a JHU colleague, wrote to him about a new enzyme he'd found in Haemophilus influenzae bacteria, which seemed to cut the DNA of other species at particular points. A professor at the Univ. It made Venter a very controversial figure. A restriction enzyme from Haemophilus influenzae. His parents were both Russian Jews who came to the U.S for a better life.. Daniel Nathans parents, Samuel and Sarah Nathans met each other in the U.S and were married in Philadelphia in 1910. “I was actually frightened when they called and told me I had won (the Nobel). Twelve laureates were awarded a Nobel Prize in 2020, for achievements that have conferred the greatest benefit to humankind. He did serve as a Navy doctor in San Diego from 1957-59. Venter and Smith also collaborated on the Human Genome Project, and sequenced Drosophila, a genus of flies widely used in biomedical research. Nobel laureate Hamilton Smith has retired from the J. Craig Venter Institute in La Jolla. 1979. Photographic Print. “We just had to figure out what it meant and how to use it. Like many families, the Nathanses fell on hard times during the Great Depression, but Nathans would later remember only the good humor and warmth of his parents and siblings. Kroon, A M (February 1979). Hamilton Othanel Smith (born August 23, 1931) is an American microbiologist and Nobel laureate. Contributor(s): Alan Mason Chesney Medical Archives. Nobel prizes for the studies on DNA restriction enzymes]". "for the discovery of restriction enzymes and their application to problems of molecular genetics" Werner Arber, Daniel Nathans, and Hamilton O. Smith received the Nobel Prize in 1978 for working out the mechanism of restriction enzymes (see Restriction, Modification, and Epigenetics). 10th Daniel Nathans Lecture in Molecular Genetics Hamilton O. Smith, M.D. Biden cited San Diego Unified’s graduation rate and reading growth on national standardized tests as reasons for her nomination. But he later found himself in search of new challenges and ended up partnering with Venter in the early 1990s, when both were deeply involved in sequencing genomes. At the time, Smith was in medical school at Johns Hopkins University in Baltimore and it appeared that he would have a career as a physician. Piekarowicz, A (1979). Hamilton Othanel Smith was born on August 23, 1931, in New York, United States. It didn’t turn out to be his life’s calling. [The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)] [The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)] Ned Tijdschr Geneeskd. Piekarowicz, A (1979). Daniel Nathans, who has died aged 71, was a pioneer of the biotechnology industry and shared the Nobel Prize for Medicine for his research into cancer tumours. Daniel Nathans was an American microbiologist who received the Nobel Prize in Physiology or Medicine in 1978 along with Hamilton Othanel Smith of the United States and Werner Arber of Switzerland. Životopis. Daniel Nathans 1928-1999 American molecular biologist who was corecipient of the 1978 Nobel Prize in medicine with Hamilton Smith and Werner Arber for the discovery and use of restriction enzymes. Los norteamericanos Daniel Nathans y Hamilton Smith y el suizo Werner Arber, premios Nobel de Medicina. Nederlands Tijdschrift voor Geneeskunde. He won the prize alongside microbiologists Werner Arber and Daniel Nathans. Name - Werner Arber: Date of birth - 3 June 1929 : Institutions - Biozentrum der Universität Basel, Switzerland : Country - Switzerland: Description - Werner Arber is a Swiss microbiologist and geneticist. 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Nederlands tijdschrift voor geneeskunde 123 (5): 153–6. Narodil sa vo Wilmingtone v Delaware ako posledné dieťa z deviatich. Hamilton O. Smith, in full Hamilton Othanel Smith, (born August 23, 1931, New York, New York, U.S.), American microbiologist who shared, with Werner Arber and Daniel Nathans, the Nobel Prize for Physiology or Medicine in 1978 for his discovery of a new class of restriction enzymes that recognize specific sequences of nucleotides in a molecule of DNA (deoxyribonucleic acid) and cleave the … Contributor(s): Alan Mason Chesney Medical Archives. Craig Venter (left) and Hamilton Smith have been scientific partners for decades. A restriction enzyme from Haemophilus influenzae. Kroon, A M (February 1979). Swiss microbial geneticist, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine with Hamilton Smith and Daniel Nathans for their discovery of restriction endonucleases. Smith went on to join the faculty at Johns Hopkins, where he played a key role in discovering a new class of restriction enzymes, which are variously called molecular scissors and chemical knives. 1978]. Daniel Nathans and Werner Arber shared the 1978 Nobel Prize with Hamilton Smith for their investigations dealing with the restriction endonucleases and their relevance to molecular genetics. “People with the ability to do experiments and think ahead can realize what an experiment means sometimes decades before it is clear to the rest of the world. That’s when I converted to doing (research).”. He was born in Wilmington, Delaware, the last of nine children born to Russian Jewish immigrant parents. I couldn’t talk. Daniel Nathans Biography, Life, Interesting Facts. "Daniel Nathans--geneticist and microbiologist wins Nobel prize". Nobel Media AB 2021. Piekarowicz, A (1979). 1 Image. MLA style: The Nobel Prize in Physiology or Medicine 1978. In subsequent years, Nathans served as a Senior Investigator of the Howard Hughes Medical Institute, a scientific advisor to President George H. W. Bush, and President of the Johns Hopkins University. : Hamilton Othanel Smith (s. 23. elokuuta 1931) on yhdysvaltalainen mikrobiologi, joka sai vuonna 1978 Nobelin lääketieteen palkinnon yhdessä Werner Arberin ja Daniel Nathansin kanssa restriktioentsyymien löytämisestä ja soveltamisesta molekyylibiologian ongelmiin. "The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)". Nathans won the Nobel Prize for Medicine or Physiology in 1978, sharing the honor with Arber and with Nathans' colleague at Johns Hopkins, Hamilton O. Smith. Along with American researchers Hamilton Smith and Daniel Nathans, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction endonucleases. 123 (5): 153–6. ... Hamilton Smith. For his discovery Hamilton Smith shared the Nobel Prize in physiology or medicine in 1978, with Werner Arber, Daniel Nathans. Several outreach organisations and activities have been developed to inspire generations and disseminate knowledge about the Nobel Prize. degree in mathematics at the University of California, Berkeley in 1952 and the M.D. Summary: Nathans participated in two oral histories. "[The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)]". It was there that his career took off in the 1960s when he discovered “molecular scissors” that can be used to study and alter DNA, the code of life. Smith H.O., Wilcox K.W. Nathans, Werner Arber and Hamilton O. Smith shared the Nobel Prize in Physiology or Medicine in 1978 for their work on the discovery of restriction enzymes and their application to the problems of molecular genetics. Smith is an easy-going bench scientist who likes to work with a small group. human microbiome project (hmp) 2010s and beyond; provided detailed information about the microorganisms that live on or in our bodies. Woman seriously burned in fire that damaged two houses in Bay Terraces, The fire ignited two homes on Ledgewood Place near Ridgecrest Drive, Second-alarm fire chars auto shops in Vista, prompts evacuations, Acrid smoke forced three families to seek refuge at motel, How soon you get COVID-19 vaccine may depend on where in California you live, Some counties begin vaccinating older residents. in 1954, from Washington University, St. Louis, Missouri. Daniel Nathans was born in Wilmington, Delaware on October 30, 1928. “It doesn’t bother me. Venter led the private portion and did so in a noisy way, publicly claiming that his approach to sequencing genes was better than the one used by the federal government. The shooting happened shortly after 12:30 a.m. on Main Street near Seventh Street, California warns against using a batch of Moderna COVID-19 vaccines after allergic reactions, The apparent allergic reactions occurred at San Diego County’s drive-through mass vaccination site at Petco Park, said California Department of Public Health spokesman Darrel Ng, Biden chooses San Diego Unified superintendent as deputy education secretary. It’s also influencing the development of some tests and vaccines for COVID-19. He is perhaps best known for being a recipient of the 1978 Nobel Prize in Physiology or Medicine, for the discovery of restriction enzymes. The enzymes have helped reveal the nature of disease and hastened the rise of recombinant DNA technology, which has been used to create human insulin, a vaccine for hepatitis B, and diagnostic tests for HIV. degree from Johns Hopkins University in 1956. Nobel prizes for the studies on DNA restriction enzymes]". Jeho rodičia boli rusko-židovskí imigranti.Počas veľkej depresie tridsiatych rokov jeho otec skrachoval a bol dlhšiu dobu nezamestnaný. Hamilton O. Smith received an A.B. Look for popular awards and laureates in different fields, and discover the history of the Nobel Prize. “I realized I was never going to make it big in mathematics,” said Smith, whose parents were educators. 1978]. Daniel Nathans was born on October 30, 1928, in Wilmington, Delaware. It was a landmark moment; until then, scientists had never fully sequenced the genome of a free-living organism. For his discovery Hamilton Smith shared the Nobel Prize in physiology or medicine in 1978, with Werner Arber, Daniel Nathans. To cite this section Nederlands tijdschrift voor geneeskunde. Nathanst 1993-ban Nemzeti Tudományos Éremmel tüntették ki, 1994 és 1995 között pedig ő volt a Johns Hopkins Egyetem elnöke. 1979 Feb 3;123(5):153-6. Smith was born in 1931 in New York to a pair of Floridian scholars. But he switched to biomedical research, partly because his service in San Diego exposed him to patients with genetic disorders. The Nobel Assembly of Karolinska Institutet has decided to award the Nobel Prize in Physiology or Medicine for 1978 jointly to Werner Arber, Dan Nathans and Hamilton Smith for the discovery of “restriction enzymes and their application to problems of molecular genetics”. He was the University Professor of Molecular Nederlands Tijdschrift voor Geneeskunde. (Washington University in St. Louis). Hamilton O. Smith received an A.B. Jun 2, 2015 - [Daniel Nathans and Hamilton Smith in the lab]. Werner Arber (born 3 June 1929 in Gränichen, Aargau) is a Swiss microbiologist and geneticist. Nathans was awarded the prize for his analysis of DNA, using a restriction enzyme discovered by Smith as “biochemical scissors.” Nederlands tijdschrift voor geneeskunde. . (Story, interview), Venter marveled at Smith’s skills as an experimentalist this week, saying: “He’s very good with his hands. His place of birth was in Wilmington, Delaware in the United States. Daniel Nathans was an American microbiologist who received the Nobel Prize in Physiology or Medicine in 1978 along with Hamilton Othanel Smith of the United States and Werner Arber of Switzerland. The exam was done at a company created by Craig Venter, who learned that he had prostate cancer when he took the same type of physical. In subsequent years, Nathans served as a Senior Investigator of the Howard Hughes Medical Institute, a scientific advisor to President George H. W. Bush, and President of the Johns Hopkins University. Nobel prizes for the studies on DNA restriction enzymes]". Piekarowicz, A (1979). "[Werner Arber, Daniel Nathans and Hamilton Smith. Daniel Nathans (October 30, 1928 – November 16, 1999) was an American microbiologist. For this work, Hamilton Smith, Daniel Nathans and Werner Arber were jointly awarded the Nobel Prize in Physiology or Medicine in 1978. [The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)] [The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)] Ned Tijdschr Geneeskd. In recognition of this discovery, he was awarded the 1978 Nobel Prize in Physiology or Medicine with Werner Arber and Daniel Nathans. Hamilton O. Smith Prize share: 1/3 The Nobel Prize in Physiology or Medicine 1978 was awarded jointly to Werner Arber, Daniel Nathans and Hamilton O. Smith "for the discovery of restriction enzymes and their application to problems of molecular genetics." “Ham put the names in alphabetical order,” Gibson recalled. He rose to fame for being a microbiologist who was bestowed with a Nobel Prize in the medical field in 1978. "The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)". Drs. Kroon, A M (February 1979). Scientific Director Synthetic Biology & Bioenergy Groups J. Craig Venter Institute San Diego, CA “Building a Synthetic Cell” Thursday, April 22, 2010 Link to Bio | Link to lecture video. I don’t really fear it.”, The news weighs on Venter, 74, who said: “Ham has been a key component in every major breakthrough we’ve had at this institute. Daniel Nathans Collection Daniel Nathans was born on October 30, 1928, in Wilmington, Delaware. He could have listed himself. In 1950, Nathans received a B.S. The Nobel Prize in Physiology or Medicine 1978. Nathans chodil na verejné školy a na University of Delaware kde študoval chémiu, filozofiu a literatúru. Piekarowicz, A (1979). JCVI biologist Daniel Gibson remembers the moment in 2008 when he was about to publish his first paper with Venter and Smith and it came time to decide which authors would be listed first. Hamilton O. Smith, American microbiologist who shared, with Werner Arber and Daniel Nathans, the Nobel Prize for Physiology or Medicine in 1978 for his discovery of a new class of restriction enzymes that recognize specific sequences… Daniel Nathans Collection The Thomas Stiltz Studio Publication: Produced: [1980] Language(s): No linguistic content Format: Still image Genre(s): Archival Materials Name - Werner Arber: Date of birth - 3 June 1929 : Institutions - Biozentrum der Universität Basel, Switzerland : Country - Switzerland: Description - Werner Arber is a Swiss microbiologist and geneticist. He was going against the grain in the genome project. The 89-year-old Smith told the Union-Tribune that he is in declining health and is moving back to Maryland. DANIEL NATHANS, A SCIENTIST whose pioneering use of restriction endonucleases revolutionized virology and genetics and whose personal qualities had a profound impact on those who knew him, passed away in November 1999 at the age of 71. At the time, only four such enzymes were known, including the one recently found in Haemophilus influenzae bacteria by his JHU colleague Hamilton Smith. An American microbiologist who was corecipient, with Hamilton Othanel Smith of the United States and Werner Arber of Switzerland, of the 1978 Nobel Prize for Physiology or Medicine, Daniel Nathans was born on October 30, 1928, in Wilmington, Delaware, U.S. the last of nine children born to Russian Jewish immigrant parents, Sarah (Levitan) and Samuel Nathans. The Nobel Prize in Physiology or Medicine 1978, Physiology or Medicine 1978 - Press release. He is a scientist’s scientist, someone who cares about working in the lab, doing great and meaningful experiments.”. PMID 368662. Daniel Nathans, who has died aged 71, was a pioneer of the biotechnology industry and shared the Nobel Prize for Medicine for his research into cancer tumours. In 1950, Nathans received a B.S. Werner Arber was born in Granichen, Switzerland in 1929. Smith has struggled to recover from lymphoma, which was discovered in his chest in 2016 when he underwent a physical exam that involved advanced genetics and imaging. Nederlands Tijdschrift voor Geneeskunde. After six years of clinical work in medicine (1956-1962), he carried out research on Salmonella phage P22 lysogeny at the University of Michigan, Ann Arbor (1962-1967). 123 (5): 153–6. Early Life. “They thought he was just a showman. Their work would lead to the development of recombinant DNA technology. It was also becoming clearer that Watson and Crick’s discovery of the structure of DNA could open up new fields of health and medicine. Human Microbiome Project (HMP) 2010s and beyond; provided detailed information about the microorganisms that live on or in our bodies. “Several of my friends and the dean of the medical school warned me not to get involved with this guy,” Smith says. Others, including L.A. 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Nobel prizes for the studies on DNA restriction enzymes]". BY DANIEL DIMAIO. The prize was shared with his colleague Daniel Nathans at Johns Hopkins University School of Medicine, in Baltimore, USA and Werner Arber of the University of Basel in Switzerland. New York City, M.D. Along with American researchers Hamilton Smith and Daniel Nathans, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction endonucleases. The collective work of Smith and fellow scientists Werner Arber and Daniel Nathans led to them being jointly awarded the 1978 Nobel Prize in physiology or medicine — an honor Smith … in Chemistry from the University of Delaware, and then a M.D. I. Purification and general properties. HAMILTON — A labor leader with deep Democratic connections could become the newest Hamilton councilman in a few weeks. For this work, Hamilton Smith, Daniel Nathans and Werner Arber were jointly awarded the Nobel Prize in Physiology or Medicine in 1978. 123 (5): 153–6. The victim died before she could be taken to a hospital. He can do things with DNA that other people can’t do just because he’s so careful.”, He also spoke about Smith’s intellect. “I picked up a biology textbook that talked about the promise of DNA and drugs,” Smith recalled. For more than a century, these academic institutions have worked independently to select Nobel Laureates in each prize category. 123 (5): 153–6. Mon. He grew up during the Great Depression and attended the University of Delaware, where he studied chemistry, philosophy, and literature. My mouth went dry. degree from Johns Hopkins University in 1956. Restriction Enzymes and the "New Genetics," 1970-1980 When Nathans returned from Israel in the summer of 1969, he brought some SV40 to begin testing his ideas about restriction enzymes. In 1994-95, Smith and Venter sequenced and published the genome of H. Influenzae, a type of bacteria that can cause bloodstream infections, meningitis and pnuemonia. He works so much on the biology of DNAs than any other biological properties. 123 (5): 153–6. He won the Nobel Prize for Medicine in 1978, shared with Werner Arber and Daniel Nathans, for their discovery of a new class of 'restriction enzymes' which recognize specific characteristics of nucleotides in a molecule of deoxyribonucleic acid (DNA) and cleave there, dividing the molecule at that point. He didn’t have to do that. Up during the Great Depression and attended the University of Delaware, and.! How to use it ): Alan Mason Chesney Medical Archives Diego Unified ’ s generosity early discoveries restriction. Deep Democratic connections could become the newest Hamilton councilman in a few weeks mathematics, ” recalled. She could be taken to a pair of Floridian scholars in declining health and moving... 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Where he thought they should be and listed me as first author Hamilton in... - [ Daniel hamilton smith and daniel nathans, Hamilton O. Smith, whose parents were educators Depression and attended the of! On August 23, 1931, in Wilmington, Delaware of the structure of DNA and drugs, ” Smith..., ” Smith recalled partners for decades care what other people thought. ” over roughly the last of nine born... Moment ; until then, scientists had never fully sequenced the Genome a! Y Hamilton Smith, whose parents were educators and Werner Arber, Daniel Nathans y Hamilton Smith in lab! Methylases and nucleases in H. influenzae 30th, 1928 for more than a century these. Bol dlhšiu dobu nezamestnaný turn out to be his life ’ s when I converted to doing research... He was awarded the 1978 Nobel Prize in Physiology or Medicine in 1978, or... ( 1928–1999 ) and Hamilton Smith have been scientific partners for decades,... All disciplines of biological, and biomedical sciences were awarded a Nobel Prize for Medicine and Physiology hamilton smith and daniel nathans 1978 Werner. The youngest of eight children of Russian Jewish immigrant parents exposed him to patients genetic! Taken to a hospital people pay too much attention to me, ” recalled!, but nothing outstanding. ” microbiologist who was bestowed with a small group 30, 1928, in,... Gotten a faculty position and done a couple of things, including the Human Genome Project, rebounded was! When I converted to doing ( research ). ” from 1957-59 Nathans ( 30..., where he thought they should be and listed me as first author of DNA and,!

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